Personally, I do not like head shots with any round because the margin of error is so high with a head shot. There is alot of non vital area around the relatively small brain of a deer that will result in a lost deer that will surely die a slow death from the wound.
I also can not recommend any tipped bullet for use on deer except perhaps the 75 gr A-Max when used correctly, for shots behind the shoulder.
I have taken dozens of deer with a 22-250 so I am not saying this round can not be used for them, just that I would not recommend a head shot and certainly not at 250-300 yards and I would never use a tipped bullet either.
If you hit the brain it would surely kill a deer instantly, getting the bullet in the correct location is the tricky part.
There are much more effective bullets like your Partition for deer and much more effective shot placement. If your concerned about meat damage, shoot behind the shoulder about 4" and you will be away from teh shoulder plenty and this is a much easier and effective shot.
May not go down instantly but they will go down everytime within 100 yards with both lungs vented.
Good Shooting!!!
Kirby Allen(50)