My copy of the Sierra loading manual lists 51.9 grains of Win 748 powder as maximum. My Remington M700 shoots sub 1/2 MOA using 52 grains of 748 with the Sierra 110 grain HP in Winchester brass, WLR primer. Bullet tip to case head measured 2.615". Since my load it 0.1 grain over Sierra's maximum, YOU MUST REDUCE THE POWDER CHARGE BY 7% TO 10% AND WORK UP THE LOAD IN YOUR RIFLE, WATCHING FOR SIGNS OF EXCESS PRESSURE.
I've been reloading metallic cartridges for over 50 years, referring to various editions of the Sierra loading manual among others. I've never had the impression that they were "biased to one specific powder".