My life long friend, hunting and reloading partner has had great success with RL22 and 180 and 200 Nosler PART's and AB's.
I sincerely wish your friend best of luck finding Fed 215M's and RL22. Brass and bullets he should be OK.
For 180-200gr pills within 500, RE25, H1000 & RETUMBO work very well.
For pills above 200gr, RETUMBO or H1000 are my go-to powders.
RE25 works very well with all bullet weights of 165gr and higher. It is a little temperamental at max loads, so be cautious.
I am finding RETUMBO to work very well with 210gr ABLR in my 300WM Sendero so far, right out to 1000.