In the world of accuracy, Weatherby seems to get away with breaking many of the rules. Belted cases, long throats, funny shoulders, less-than-perfect triggers….. yet, somehow they mike a darn nice rifle that puts the bullets where they're supposed to go. My .300 isn't all that particular but with a little trial & error I've got it shooting reliably inside 1/2 MOA with 180 gr TTSX. That velocity with that bullet is a terribly good combination. So far it has worked on everything from coyotes to eland & moose. The .30 Nosler looks pretty good at first, but really, you're not really gaining all that much.
The cartridge I think still has the most untapped potential is the .257 Wby. Get that in a 1:7 barrel with heavy, long monolithics and it'll be a game-changer.