At lower impact velocities, ie longer range, bullets will upset/expand/fragment less and penetration so be deeper, so long range shoulder penetration concerns are really misplaced.
The limiting case for bullets and adequate penetration is actually max velocity impact, ie 20 yard shots, into bone or very dense tissue. Even so, 225 gr is a lot of mass, extreme tissue damage is much more likely than inadequate damage.
This forum isn't much of a hangout for terminal ballistics knowledge, another place has a pretty good repository of field autopsies that show actual wound channels in tissue. I would shoot that 225 eldm without reservation.