I shot some Sierra 75 gr HPs in my 25-06 with Sierra's manual Suggested Accuracy load which was also there Suggested Hunting load which was 49 grs. IMR 4064 and it ran around 3600 fps and was pretty accurate. Rem cases and CCI BR2 primers is what I also used. I settled on this load for my varmint load. Sierra 87 gr SP, 52.2 grs IMR4350, Rem case, CCI 250 mag primer, OAL 3.150, average 3300 fps. Bug hole accurate and red mist and scatters pieces on a ground hog.