Not one thing wrong with the ought-six unless you have a need to save the skin. This is a favorite cartridge for antelopes, often requiring long-range shots, but it is just fine for smaller animals as well. I use either a .270 or a .22-250 for coyotes. Either cartridge nails 'em. It depends on which rifle I have sighted in and for which I have some reloads available. I don't save the hides and don't care what I shoot them with. I prefer the .270, merely because it weighs a lot less than the 250 and is a repeater, whereas the 250 is a single shot, far heavier and set up for bench rest. If I had my druthers, I would buy an AR-15 type rifle in .243, but our genius politicians in California have outlawed purchase of these types of so-called "assault weapons." As a result, I am considering a .243 in a Browning BAR or Savage bolt action. Haven't decided yet, but I have more than enough rifles to take care of Wily.