I too have been interested in this one. It looks pretty efficient, I bet you could use 22-250 brass, the Sierra Reloading manual says they use this cartridge for accuracy testing for .25 cal bullets. Thats where you can find load data, Sierra Edition V. It'd be cool in a handgun too. I wish Hornady would make an 87 grain v-max, I just emailed them about it. Sierra says with 43.2 RE-15,26"1-10,you can push a 75 grain hp at 3600 with max load, also their most accurate load.