There are things to consider that I know are contrary to common notions.
1. New brass poorly represents YOUR cartridge, that you form in YOUR chamber.
With firing, even once, brass is forever changed, and cannot ever be what it was again.
FL sizing makes no difference about that.
2. Your dimensionally stable brass fits your chamber differently. The clearances are not the same, and the upsized/downsized brass grain has changed spring back from new condition.
3. Given changed H20 capacity, and changed case hardness, and changed chamber fit, pressure from a given powder load will change. Barrel timing will change.
Why chase change?
4. The goal should be to take your cases to stable(unchanging) as efficiently as possible. THEN, work methodically towards a best load.
If losing sleep over extra shooting in this, then test seating and do primer swaps while fire forming. Barrel break-in, scope sighting, shooting the bull with friends, etc.
And consider whether you really need 100 cases at all.
I've shot out several barrels, and killed hundreds of groundhogs, with the same 50 cases. Yeah, I fired an extra ~150 shots with the first barrel I suppose. But I didn't chase my tail firing so much to find a great load. That was easy.
Can't say for sure, but it's possible that I didn't 'waste' anything with this approach.