For my .375 H&H I use the Speer 285 GS. I have taken several Oryx and they usually drop in their tracks if shot through the lungs with major exit wounds.Mine is a Chas. Daly 98 Mouser, I use 79 grains on RL 19 and WLRM primers, Hornady, Nosler, Norma, R P, or PPU Brass.