Depends on uses too. I had issues with hangfires in a .270 Sherman using 60.6 grains of rl26 and a 170 EOL going a mild 2850 using BR-2's in low 30's and 20 degree temps. But that was a combo of a slow burning powder that tends to do better with a higher pressure ignition, low case fill, and cold temperatures. I have used BR-2's in 7mm rem mags with success, even in cold temps. But, that was with pretty high case fill of H1000 and Reloder 26, and honestly I prefer to use mag primers, they have not been detrimental to getting consistent velocities, so it takes away any worry of having ignition issues with zero performance penalties.
I'm sure you could use them, probably without any issues, but in a 300 wm, I would personally try to find some Federal GM215M primers, or large rifle magnum gold medal match primers, especially if you hunt in cold conditions. If that isn't an option, try CCI 250's or Federal standard magnum primers. If it doesn't like them, try Remington mag primers....I would be really surprised if you didn't find acceptable performance with any of those.