Overbore, it shouldn't be any problem applying that Sheperd for LR with whatever load u're using. I'm using a 22LR BDC reticle for an AR-15 .223AI load, and it's working fine. It's certainly not set up for even 100 yd. intervals, but all i need do is look up at my BC scope cap cover where i put my range sticker, and the info's right there, quickly applied.
What i'd do is just go out and measure each tic mark (stadia) along the reticle @ 100 yds. (or 50 and dbl. it) from center x-hair as close to .1 inch as possible. Now divide each of those figures by 1.05, and u now have the measurements in MOA. Now run a ballistics program, and match up the MOA stadia zeros with the drop in MOA that the ballistics program calculates beyond your preestablished zero. Now what i do is i make my range sticker up in 50 yd. intervals to as far out as i wanna go. Often i won't even know what a particular stadia's zero actually is if it doesn't fall on a 50 yd. increment. When it comes down to it, the stadia are really only there to provide a reference point for interpolative purposes, since game rarely shows up at the exact range of a particular stadia. Here's what a range sticker may look like for one of my rigs, with range, then elevation, then 10 mph windage--
450-2.9-.5
...so if i have a coyote @ 450 yds. aim 2 stadia down + 9 tenths of the way to stadia 3, and if i have a 10 mph wind aim 5 tenths to the 1st windage stadia. Put it all on a range sticker and slap it into the Butler Creek scope cap cover. This is the easiest and quickest reference system i could ever come up with for LR shooting with a ballistic/ranging reticle.
1 other thing-- be sure and verify the actual x-hair zero, as any deviance here will be pronounced downrange.
Nikon is doing exactly what i just described to you about providing exact stadia zeros for your particular load that Sendero mentioned earlier (nice thing about the Nikon system tho is that they give u very precise and thorough reticle subtensions in their catalog. I don't know if u can get that info from the Sheperd guys--might tho. Could be worth a phone call, and will be easier than measuring them). Nikon probably won't provide interpolative zeros for the in-between stadia, tho they may. Hope this helps some.