I'm going to add a little more to it. You can pretty much take a barrel off and screw it back on if: your scope is high enough to allow it, and if your barrel channel is wide and deep enough. So plan ahead. Make sure you have the clearance to do that. If you can accomplish this then the POI is not even my previously said .2 moa change. I can and have shoot the barrels say 600 yards and out to 1000 yards, screw it off and back on and you really can not notice any change. Where you get into the minimal change is if you don't have the scope and stock clearance and you have to loosed the action screws to get the barrel off because the scope is too low or the channel not allowing it then that's when you may see a minimal .2 moa shift. I hope that explains it. I just hand tighten the barrel so it can all be done in the field. I've never put one in the vice to tighten or loosen. It's a great system, it's accurate, smooth and it by far is my favorite gun setup.
I am planning on making a short action one and have two bolts for 223, 6mm CM, 22 CM and 308 then give all my others to the kiddo's leaving me with two rifle actions and several barrels. My kids are rotten.
