Sorry for the short notice on this question, but it just came to me as an afterthought to put the question to all of you. I will be leaving tonight at 7:30 pm and will check for replies before I leave. Here is the background information: A buddy of mine was lucky enough to draw a public land buffalo tag here in Wyoming. A few weeks ago he asked if he could use my 338 LM to shoot the bison, as he did not have much confidence in his 30-06. Since I was accompanying him on the hunt any ways (as an official photographer, knife sharpener, and pack mule), I gladly obliged. He is planning on shooting the biggest, meanest, and oldest bull that he can find and would like to dispatch it efficiently. He's Ok with shooting it through the front quarters (shoulders) if that will kill it quickly. He considers 150 yards as long range and has no intention of taking a shot beyond 200 yards. With that in mind, I loaded up some old 300 grain Winchester Western, Round Nose Power Points, that I had on hand (these bulltes are no longer available). The load is 90 gr H1000, 3.588 OAL, roughly 2700 fps, and sub-MOA accuracy at 100 yards. He asked me yesterday where he should place the shot when he takes it and if I thought that the bullet would penetrate through the front shoulder of a buffalo. He's not 100% confident that he can place the shot perfectly on a 'back-of-the-neck-shot' and doesn't want to damage the cape either. So please help me with your wisdom and experience on shot placement for bison. P.S., Assuming my buddy fills his tag this weekend, I'll post the results of the shot, pictures, and the story.