Shot my first two ladders today, nothing changed but the powder. Both shot at 300 yards, plotted each shot on a target at the bench indicating the impact with the powder charge for that shot. No signs of excessive pressure for either powder. Rounds were fired at the same aim point with two targets hung vertically to catch all the rounds. Aimed at the center of the top target. 260 Remington 140 gr Berger Hunting VLD Nosler Brass BR2 Primers Powders: H4350 - 41.5 - 44.5 grains RL22 - 43.0 - 46.6 grains Here's the result of the H4350. Rounds fell onto both targets. 44.2 grains is down toward the bottom. And the RL22. They all fell on the second target. I know 300 is usually the minimum for a ladder, and I'm wondering if there wasn't enough range to really spread them out. I'm surprised that none of the rounds of H4350 impacted higher than the lowest powder charge. My other 260 likes a max load of RL22. 45.7-46.6 of RL22 looks like it's work exploring. 42.4 - 43.6 in H4350 looks like something to try, just not sure I'm going to get the velocity I want from that charge. These were not shot over a chronograph.