i shoot till i see the groups start to get bigger or about 25 rounds. then do a cleaning. but i have a new gun thats only burns 15-17 grains of powder and is only pushing the bullet at 1100 fps. this is in a 338cal bore. i went to the range and forgot my cleaning kit. went home at 65 rounds though the gun with no cleaning but still grouped good. how many round do guys put down before you clean.