I just sold my Ruger .22-250 that I owned for many years so I now have a need for another .22 caliber centerfire. Here are my questions: 1. Which caliber would you buy for varmint and target work out to 300-400 yards? .223 or .22-250? I have dies for both. I was going to get a .22-250 but am wondering about barrel life. 2. What twist barrel would you get? 3. Which mfg./model would you get? Weight is not an issue because it will not be a walking gun. I prefer synthetic stocks, but its not a show stopper. Accuracy is most important consideration. Thanks!