I don't fool around much with the .243 any longer, mostly I am shooting long range with a 6mmBR 1-8 twist with Bergers. Best powders are Varget and RL15.
I can tell you that all VLD bullets are very tricky and finding a good load can be frustrating. Some days the VLD will shoot well, other days like crap. If the barometric pressure is high, they might shoot well, but when its low, they could flop. In general, most competition shoots jam VLD's into the lands from .005 - .20" for best results. You really need to do a lot of experimentation with VLD's. You might consider the Berger 108 grain match 6mm, which is what I mostly use now.