I've shot hundreds of them through my 7WSM I think they're great. Killed several elk, deer, and black bears. I don't see any reason why they won't work just as well from a 280 AI. I was using 62 grains of H4350 and Fed. GM215M primers. I was able to get lots of sub MOA groups with it at 100 which would expand to over MOA at 850 (11"). I put one through the front end of a 6 pt bull at 750 where it was nicely mushroomed and against the hide on the far side and another 3 entirely through a 6 pt at about 100 yards. Great bullets!!