The only thing I can add is to mention the limitations of a 22-250 in the wind, and in my limited experience, the wind is blowing in antelope country most of the time. I shot my first antelope with a 22-250 probably 40 years ago, using the old Nosler solid base bullets (did they call them Zipedo's then?) of 55 gr. and it was a very long shot but with no wind. Killed him dead.
I put that 22-50 together before Rem standardized it and have shot several deer (all the small Southern Mulies- about like a blacktail) and all have been good hits in the rib cage and they died just like they would with a 270. The problem is that the 22 kills fine with a good hit, but one gut shot or maybe even one shot in the meaty part of the shoulder might go for days. I'm 70 and have been hunting javelina for 40-some years and get one nearly every year and I 'd guess that pigs are about as broad thru the chest as an antelope, and equally as light boned. I gut shot the first one I shot and it put him down (it was running at close range, and I was impressed with it's speed), but all others were good hits, and the 22-250 and more recently my 22BR have done just fine, but still, a 243 or 25 of some kind are better unless you have the dislipine to pass up the shot if it's iffy; you owe it to the animal to kill it quickly. Most of my hunting buddies use their deer rifles- can't kill them too dead.
