Any bow can shoot any broadhead so long as its tuned properly with the correct spined arrows. Mechanicals are not an excuse to not tune your bow.
That said, if your looking at mechanicals try out the Grim Reapers. They shoot great and do a heck of a job!
I have a buddy with a 300 WSM. That gun loves the 165 gr. fusion ammo. Under an inch at 100 with no real rest. He shot a 370" bull elk last year with that gun and it was DRT. Bullet performed great! Shot was a tad over 350 yds.
Based on that and other friends killing muleys with the...