Heavier 115 - 120 gr loads
Haven't returned to this thread in a while. I see a couple of guys have asked about heavier bullet loads. There are some excellent longer, heavier .25 caliber bullets avail including the Sierra Gameking, Nosler's superb 115 grain Ballistic Tip & Partition, and the 115 Berger VLD.
My last three mule deer, from 175 - 400 yards, have been shot with the 115 gr Berger VLD. It's a high BC bullet, capable of great accuracy and holds velocity well even at longer ranges.
Loading data for the 115 - 120 gr bullets is readily avail from Hodgdon's web site. For the 115's I went with Retumbo powder, and found that my particular rifle produced greater velocity than the load manual indicated, reaching nearly 3200 fps. A slick, high BC 115 launched at 3200 fps is very effective on deer, even out at 400 yards.
I believe other slow-burning powders would work as well, but I was so happy with the results from Retumbo, I haven't tried any others. I stick with H4350 for my 100 gr loads and Retumbo for the 115 gr loads. So far I've limited my loads to Federal 210 match primers and I neck-size only with a set of Wilson BR type dies.
Your mild-recoiling .25-06 is a quarter mile deer rifle for sure, likely capable of far more than that in the right hands.