For accuracy, I've had very good results with the 260 gr Nosler Accubond (which has a decent BC) and Nosler claims they'll open up down to 1800 fps. I've not yet shot any game with them, but dang, they're accurate! Have been told that they perform very well on elk & moose.
Here's some of the bullets I've been working with from my .375 H&H:
Sierra's 300 gr SPBT, on the far right, has also been very accurate and I've heard good things about them on game, even Cape Buff.