One thing I consistently see on many big games animals is guys shooting too far back. Not due to a bad shot but due to an improper aim point. Many guys don't realize that the shoulder angles forward like it does and that the vitals are directly above and in front of the front leg not behind on a broadside shot. If you put a bullet in front of the leg on this picture you will take out the heart, lungs and arteries and he isn't going very far. But just look at what many consider to be the correct aim point, the pocket just behind the leg. You will be lucky to barely hit the lungs. This is the area where elk will suck up a lot of bullets. I think one of the reasons that the high shoulder shot is working so well for guys and becoming so popular is that it is one of the first recommended aim points that actually gets shooters on the correct side of the leg, where the vitals really are.
I hate to even mention what my best performing bullet is on elk when shooting short to medium distances with my 06. A 165gr Hornady BTSP. I have had more 1 shot kills and DRT shots with that bullet than any other.