I shoot a 300 RUM with a custom load. Scope wise, I use a Schmidt & Bender PM II. I always dial both elevation and windage (my turrets are mil/mil, but moa vs. mil is just personal preference), so I'm holding dead center. I have a tactical mil hash reticle, so, for shorter distances, if I'm in a hurry, I can easily holdover. I also use a cosine indicator
and anti-cant device as well.
I'm not sure I would ever feel comfortable using the "drop in inches" from a drop chart to holdover significant amounts (probably anything north of 12 inches). I actually deleted the "drop in inches" from my drop charts because it just clutters everything up, and I never need it because I adjust my turrets. I'm not familiar with your scope specifically, but, in my opinion, if you are long range hunting you should be taking shots only when you are really comfortable that you can put a bullet in the vital zone. I'm most comfortable using the methods and tools I've described above, but that is just me. The most important thing is to be comfortable and confident with whatever method you use.
Play around with a ballistic calculator and validate everything at the range. If you haven't developed a drop chart it can be a very insightful process.