I shoot a 115 Berger about 400 fps faster (240 Wby) than you and there are days in Wyoming when 500 yards is really a tough shot even with the extra speed and BC.
Listen to the weather forecast. When a front is moving through, the wind blows relentlessly and it gusts frequently and hard and you just can't outguess gusts. After the front is gone, on most days, you will have about one hour every morning from first legal shooting light to half hour after sunrise of mild winds about 1-5 mph. Get up early and make the most of that time of day. Your laser range finder also works best that time of day. In the rolling sage brush you may not be able to range more than 500 yards some times of the day unless you use a Swaro.
A good set of binoculars will allow you to determine the difference between a very small buck and an doe. This is a very common mistake and result is a lot of embarrassment and or citations if you have already killed a buck.
A 1K F-class 10 ring is about the same size as the kill zone of an antelope. Get a couple of cactus from your wife's potted plants and take them to the range. Throw them down on the ground and get down and lie on top of them and if you can still hit the 10 ring you are ready to go antelope hunting. Of course that will be after you are released from the emergency room after your wife discovers what happened to her plants
Antelope have extremely fragile bones. Think of them as a small spike whitetail buck with osteoporosis. You can kill them with almost anything as long as you can hit them. So it is most likely that you will be limited by wind, or rangefinder or optics or shooting skill.
About every other year or so, it will snow or hail and or do other stupid weather type things while you are trying to hunt.