Ive posted this story before.............The one and only Bull Elk I shot was hit with a 180gr bullet out of a 300 Win Mag. The bullet hit him right behind the shoulder and broke the other shoulder on the way out. The Bull walked up a hill and turned back and looked in my direction before going down about 3-4 minutes after stopping. If he had taken off at a run he might have gone 300 yards plus. This was a big Bull that scored 320
Point is that even when well hit with a 300 Win. Mag and a good bullet there is No guarentee that all will go well, you just dont know what might happen.
I once talked with a guy that shot a Grizzly in Alaska with a 300 Weatherby and even though the bullet tore up his lungs and he hit the dirt with the shot he still got up and ran 150 yards. I hit a coyote with a 22-250 and a 50gr V-Max he ran almost 100 yards with a huge exit hole about 3"x3" out the Lung.........In all due respect he should have dropped at the shot.
All you can do it to spend a lot of time shooting and really know your rifle and then give the animal all the respect and put the bullet in the right spot.
Out in Nevada where I hunt its usually all open basins of Sage Brush and you can see where they go, unless your in Juniper tress or Aspen's.
Thats what makes all of this just that much more interesting.