Wasn't really hunting them the one time I shot a big Rio down in south Texas in the Spring of 2010. We were on a hog hunt and I had my .243 Sako along in the blind when a nice longbeard came straight down the sendero and it just happened to be opening day of turkey season. I put one in him right above his beard and didn't ruin any meat at all on him.
It is the challenge exactly! You must maintain your focus to put that one bullet into a small target. I have always wanted to hunt turkeys but only with a rifle. I started hunting squirrels with a Remington pump .410 shotgun as a kid but as an adult I only use a scoped .22LR for the same challenge. One shot, one kill.