Re: .280 for Moose..??
Bullet design is key in every caliber you hunt with. If you are reloading, many bullet manufactures have data in which they recommend a specific bullet matched with velocities for optimum performances for certain game categories. Lets say for instance, one wouldn't load a bullet designed for a 22 hornet with its thin walled jacket and push it thru a 220 swift and expect entry and exit wounds. The splat factor would be off the charts. Do the homework, select the bullet design specific for game you are hunting and optimum velocities which the firearm you choose and punch rounds down field at targets until you can hold some decent groups. Oh, when a moose is in your crosshairs, calm down, take deep breaths, hold steady and squeeze the trigger.