OP, My only Moose was in Seward, AK before The Pipe Line, mid AUG about 1972 ish.
Long story short, for 45 years I used W Mod 70 FW .270 / WW 130 gr Silver Tips except for that trip I got some 150gr Core Locks for BIG BAD STUFF! Cuz and me were climbing up the Mt. for a white spot-Billy Bob- and come across a box canyon with a snow cap in the bottom.. There was a young Bull Moose down in the middle in high weeds (they were 3-4 ft tall) so cuz sneaks 250 yds down the side of the canyon to try to drive him out in the open. About the time he gets to the bottom the Moose took a couple steps out from behind the clutter that had me blocked from a clean shot and stopped broad side. Put cross hairs of the K-4 centered right behind the shoulder and sent first round down 250 yds (guessed range) at about a 35 / 40 degree slope = about a 50 / 60 yrd Horizonal shot-(Guessed drop). Nothing moved and saw nothing of hit in snow. Held up about 3 in higher on him and fired # 2 – No movement or hit in snow. Laid cross hairs on his back and fired # 3. Still no movement or hit in snow. He had no idea where I was or what was going on.
I started thinking “...he is in the middle of a box canyon and I can shoot all 5 of my rounds before he can get out of my line of fire” so I started pushing 3 new 150s into the Mod 70. About that time he shook his head and fell over DRT! When we got to him I had put all three in a vetrical 7-8” line from dead center behind shoulder to top one just under his spine. I did that off hand / knees maby but no other help.
With this information you can see what a one year old bull did – with three through the boiler room he just sucked it up and stood there cause the sound echos must have been all over the place. But, it only took 35 / 45 sec. (Total time) before he went down. No Idea what would have happened if I had picked the center shoulder, which is what I would do today with my Tikka T-3 in 338WM and 225gr MRXs at 2,995 / 3,005fps.--My one load.
In CO for ELK I now shoot factory-Hornady Superformance 185 GMXs cause they kick less and are a little faster and NELLIE likes 'em. Barnes quit making the SHORT 225 MRXs and that is why I have a life time supply......I'm saving mine for “ BIG BAD STUFF” if I ever get to go to AK again. If you are like I was back in the 1970s -one gun for North America – go for it and use the biggest .270 round that your gun likes. Good Luck.
__________________ "I'm better when it's breathing" Chris Kyle NRA Life Member 1970
Yep - 270 will work great. A 150gr bullet and down it goes. Moose aren't that tough to kill. A 260 or 6.5x55 is plenty. Heck, a lot of moose are killed during the winter hunts off snow machines with .243s. However, for out of state folks hunting in the fall...... often there are bears that are not so wimpy where you find those moose - so going bigger has as much to do with them as to do with the moose - and if you wind up having a brownie that you can't see, huffing and popping his teeth at you from 20 feet away, through brush that is over your head then a 375 H&H is gonna seem small.
270 will work, bullet placement is key with everything you shoot at.
my tc contender 23" 30/30 dropped one last winter hunt first round in the rib cage. second base skull and neck bone. the 270 has a little more power than the 30/30.