I backpack hunt in one of two ways, depending on how far in I am nunting, what I am after (deer or elk), and how much help I have.
If I am in 6 hours or less, I tend to use ultra-light pack equipment, including the backpack, and leave my heavy pack at the trailhead along with an extra bag, mat, and food. For deer, I will pack the meat out in one trip and then go back for my camp. If we are able to spread out the meat between buddies, we can sometimes come out in one heavy load.
If I am in farther than that, I and my buddies take our Eberlestock packs in with us. This gives us more options since we can pack 100 lns or so if necessary.
My ultra-light pack and gear weighs between 35 and 40 lbs depending on weather and how long we will be out. Food is between 1 and 1.5 lbs a day. My packs going in have weighed as little as 55 lbs and as much as 92 lbs.
As far as cleaning the blood out of your pack, I use soap and water. My Deuter was quite a mess after I returned from Wyoming this year and a ligttle soap, a rag, and 5-minutes with the hose and it looks as good as new (alomost). On my camo packs, you can't see the blood
By the way, Partisan 1911 summed packing out correctly as 99% mental.