My experience with Barnes is limited but I load them in almost every cartridge .243 cal and above and I have a load that shoots 3/4 MOA or less in every gun and my best load will shoot them into a .3 inch group at 100 yards (this is in a 338 Lapua shooting the 280 grain LRX) so I am completely satisfied in the accuracy department.
My dad shot a black bear this spring with his 300 Rum and 180 TSX and he spined it.
My dad shot his whitetail doe last year with his 25-06 with 100 grain TSX at 50 yards and hit it in the shoulder and she ran with her head down spewing blood for about 20 yards and face planted, the insides where torn to shreds and there was a 3/4 inch exit on the off shoulder.
I shot my youth deer last year in ND with my 7mm-08 and 140 grain Ttsx at about 30 yards and she was beded down quartering away and the bullet entered just in front of the hind leg and exited the center of the chest. The intestines were hanging out of its side and she was DTR.
I shot a mule deer doe in MT last year with my 7mm-08 and 140 grain Ttsx at about 30 yards off hand, she was facing me and I shot her kinda low in the chest and the bullet caused so much hydrostatic shock that it tore the skin on the bottom of her chest from the shoulder to about the center of the gut and exited her rear end!
She turned and fell down a steep mountain side dead.