I just replace the original stock on my 110 (22-250) with a Boyds thumbhole. I pillar bedded it and used Devcon plastic steel. It took my loads that shot 1/2moa or better and cut em in half. With the original stock I always had muzzle jump that would take my sights completely off target, the new stock put a stop to that, at 300yrds my cross hairs never leave the target, and now felt recoil is more along the lines of my 10-22, not that an 11lb 22-250 has much recoil to begin with. But it is a completely different rifle now.
Keep in mind the animals we shoot for food and display are not bullet proof. Contrary to popular belief, they bleed and die just like they did a hundred years ago. Being competent with a given rifle is far more important than impressive ballistics and poor shootability. High velocity misses never put a steak in the freezer.