Re: 22-250 or Swift & 22 cal VLD's?
If you want to knock off P=dogs pick one and start kill'n. Now F-class is a different story. If you don't shoot a .223 or a .308 you can't compete in F T/R you are going to have to compete in F-open. they call it open for a reason. All of the calibers mentions may fly strait and kill dogs at long range. The problem is when you are on the F-class line you are competing againts the likes of the 6.5-284, the 6mm-284, and Something I recently heard of (can't confirm this yet) the 6mm-300 which uses a necked down 300 short magnum case. you will be competing with anything less than 35 caliber. all of these will out shoot the 22-250 or the swift when you are talking about hold the x-ring at 1000 yards. Another problem you will run into is an F open gun can weight up to 22 pounds. the big magnums you will have to compete againts don't hurt and be shot repeatedly and well when the gun weighs 22 pounds. What I'm getting at is while the calibers you mentioned can and will hit targets in the next zip code they will get bet up pretty bad with the likes of what you will find at an F open category match.
My personal advise is build a heavy F-class gun for long range targets and build a varmint gun for kill'n
.308 Howa 1500, varmint supreme. 24" .820 barrel, Roedale precision brake.
.223 Howa 1500, varmint supreme, 24" .820 barrel.
RRA 20" predator pursuite, Magpul PRS, ALG trigger,