2 years ago I did some work with the 50 grain Varmint Grenade and found some real accuracy issues with them in my .223. In my 22-250 I couldn't find a load that they suggested the bullet would hold together. I loaded it light and still couldn't get consistant in my 22-250. Lost interest in the bullet as I was also finding large weight differences between them.
From my experiences I would suggest a different bullet. I fielded about 100 rounds of V-Grenade and didn't find them any more 'explosive' than the same load with a V-max.
Unless you're shooting at least a 1:9" twist barrel, the accuracy will probably not be phenomenal. I had contacted Barnes about this bullet, and they said to stay with the 36gr VG. It has to due with the length of the bullet, due to the fact it is lead free, rather than the weight.
I've always threatened to try the 36gr. VGs out of my .222 Rem., but I still haven't done it lol.
50gr VMax, 35gr Varget(37gr MAX), Nosler brass and CCI 200 primer gets 3/8in 3 shot groups out of 700 VLS .22-250 with 2.35in COL. There are a lot of powders that can take the 50gr V-Max into the factory 3850fps range. I get ~3900fps.
I tried the 36gr VG in my 1:9tw Panther Bull .223 AR and best I could do was .7in 5 shot groups at 100 yards. I get .48 - .6 5-shot groups with 40gr-75gr bullets of various breeds. That 36gr is very delicate bullet, it is about the same length as 50gr bullets. It is very hollow and thin jacketed.
I haven't given up on the 36gr, I plan on going back with Benchmark and some experimenting with shorter OAL on .223. I loaded some up in .22-250, but haven't taken them out for a test.
0.7" group at 100 yards is a varmint killer for sure
I would go with that! That's certainly adequate for squirell shooting in the CA Condor lead free zone, especially when afternoon coastal breezes limit most shooting to within 200 yards, give or take...
I have a 22-250 Remington 700 VS and for the life of me I could find no load for it that shot better than 1.5 MOA at 100 yds. I finally bought some 52 gr Berger Varmints and behind 33.0 gr of IMR 4895 it shoots about 3/8" groups at 100 yds. Its the first load I have been able to shoot the heads of bowling pins with at 300 yds and hit them 9/10 times. So I would suggest trying the bergers also.