If you're going to use Varmint Grenades, don't waste your time with the 50grainers.
Instead, use the 36grain Varmint Grenades. The 36gr VG's are as long as a 52gr Amax. I used the Varget load data in the Hornady manual for 40gr Vmax with good success. They are not as spectacular as Vmax but still impressive on little critters.
H380......... That is all that needs to be said for the 22-250 and 50 grain bullets.
I have tried most suitable powders for the 22-250 and always come back to H-380. From 37-42 grains depending on your rifle. I found no accuracy differences just different speeds. I never weigh it out anymore. It throws within 1/10 of a grain for 10 charges consistantly. You read that right. When I set my measure I pump 10 charges into a pan and adjust until it throws for example 400 grains dead on. Once set it will repeat this level of consistancy time after time. Then I just throw 50 or 100 at a time. I can charge 100 cases in about 4-5 minutes. Now that I have a Dillon I may try loading it on the progressive press.
I use CCI-250 magnum primers. I load this for many different 22-250's and it will show you what your rifle is capable of. Both of my lowly Ruger varminters shoot 1/4" groups out of a couple factory barrels that are now well over 7000 rounds each. It burns really clean too. I have better luck with Winchester brass. I used to seat my bullets a certain distance of the lands but now I can no longer get any where near the lands with the bullets falling out of the cases so now we just seat so they will feed and we are good to go.
The BD 8-32 is a great piece of glass. I had one but could never get used to the overall size of it and sold it in favor of some fine plex Leupolds.
"Only accurate rifles are interesting".
If you're loading several hundred rounds on a progressive press for a PD hunt (as I have for many, many years), the BTs are easier to line up, start and seat in the cases than the FB variety. Much less fumbling around and cussing.