Re: 204 ruger or 22-250
Hehehe, and then the talk went to ARs. I totally agree; ARs positively RULE in a PD town! Accurate ones that it. Don't forget the brass catchers!
I have three uppers built for me by ISSI, Insight Shooting Systems of Colo. All will shoot bug holes all day long. Two are in 20 TAC (driver) and a 223 A.I. What is so great about them; besides their super accuracy, is the lack of recoil and I can see impacts.
The 20 TAC (driver) is first cousin to the 204 Ruger and the 20 Practical. It's the smaller of the three and I believe the most efficient; but it's a small point. My 20s love the 39 gr. Sierra Blitz Kings and the 223 A.I. loves the same brand at 55 grains.
So as to your quest for the best PD round. I'm doing mental back flips over my choices. I can whack em with the 20 out to 475 (did it last year); but there ain't much energy left for PDs. (Lee of ISSI regularly shoots coyotes with it at long ranges. ) The 223 A.I. sends a 55 grainer , I swear it's true, at a tad over 3600 fps and will reach out to ,I think , over 500 yards. Neither round in the real world of PD shootin takes much hold for wind. It blows oddly all the time anyway so luck plays a big part in doping the wind out there.
For my 2 cents worth; for PD shooting mostly, go with a 20 cal. and a 223 as the range get longer or the barrel get hot. Oh, and do it on an AR platform with a good built upper. It's worth the expense. ISSI is great and I'm sure there's other makers. You won't be lugging these all over so make em heavy; at least a .700 muzzle for the 20s and 850 for the 223 and you'll see the PD explode ! Oh, and don't go over 10 power in the scope while shooting. It's all you need. I shoot higher at paper; but not PDs. Can't find them first and harder to see impact with higher than 10X.