Depends on the situation / time of year. Here in California we can shoot em as close as 50 yards to out past 1000 if one needs/wants to. I use several different AR-15's in 5.56 and an old Ruger .220 Swift that'll still post 3 shot .188's with a 40gr BT in front of 40gr of Varget for about 4150fps.
If the wind kicks up I'll move up to my Weatherby Super Varmint Master in .243. If the wind is REALLY howlin I'll break out the Accumark in 30-378 shooting 130gr G&S Customs at around 3700fps, not much of a hide saver but it absolutely proves old Roy's theory of hydrostatic shock