heck yes. They are tough as nails. I shot one with my AR a month ago as he was running away. I tracked a decent blood trail till dark:30. Then I and a friend took it up in the am again. About a mile away we lost it. On the way out we saw a yote mousing in a wheat field below us. So we went to the truck an got a rifle. Then set up and dumped him. It turns out it was the samer yote. The night before I had hit him high in a rear leg, and put a hole through an ear as well...

Yep you guessed it, it was one of those "spray and pray" deals.
Anyway the last two have been with the .338 and 300 Bergers. Never tracked them far...
Jeff