If you really want to be a top dog in the predator hunting area dont worry about what size cal you need. I've been hunting and tracking coyote for a very long time and found out along time ago the better you call the closer they come to you. I use a little old .17hmr Savage and out kill most of my buddies with their bigger calibers. Most of them dont call very well so they always want me to go to do the calling and when I do the yotes come in so fast that they dont get a chance to sight in on them befor the yotes are with in 30 to 50 yrds. So learn to call and let your buddes want to take you hunting its great having not to pay for the gas with so any of your friends wanting to use your calling experince in calling. PS. I sell my fur and not having them all torn up from a.larg cal gun getse more money!
Well any calling tips you'd be willing to let loose with
Keep in mind the animals we shoot for food and display are not bullet proof. Contrary to popular belief, they bleed and die just like they did a hundred years ago. Being competent with a given rifle is far more important than impressive ballistics and poor shootability. High velocity misses never put a steak in the freezer.
If your goal is to build rifle on your long action that gives you more power & range, the .25-06 would be my first and last choice. Bullet choice then becomes the question with two directions to go: light fragile bullets that will break up and hopefully not exit, or copper solids that will pass through with only a small exit hole.