I would never sight in a gun for more than 3/4ths anticipated target size. This means that for an ~6" maximum target size for a broadside coyote, sight in the rig for a conservative MPBR of 2.3-2.5" above line of sight. If you try the liberal MPBR sight in system where you're trying to stretch PBR to the absolute maximum you're PROBABLY gonna shoot over some coyotes, and when that means 1 coyote called or encountered in a full day of 5 degrees coyote hunting
that's a big price to pay (it has been for me at least).
If you're shooting a 9-10" twist 22 barrel i'd suggest the 65 Sierra GK. I think that bullet is the best for all around coyote hunting--short to long...er ranges.
I used the 40-45's for a number of years and liked them for their fur-friendliness (relatively speaking), but since i'm not killing 40-70/season as in days gone by, i shoot whatever works best to long range and just sew when i need to.