Yes, I am thankful that we had the opportunity to move out to the country a few years ago. As for the family, they get used to the 6am gunshots. My wife told me yesterday she "vaguely" heard it in her sleep, when I asked her about it. LOL
Concerning your muzzleloader, I say go for it if they come in close enough. It's not quite the same as using a 300 RUM in that it does present a challenging shot, but keep in mind that you're still gonna have 2 big holes in the hide if you plan in keeping the pelt. Shooting fairly cheap factory loads in my 22-250 (Winchester 45 gr. hollowpoints at 4000 fps) I get one small hole in, and many times no hole out. It does tend to give them hemmorhoids, though, as it blows stuff out their rear end!
Sighted-in 3" high at 100 yards keeps it pretty flat shooting out to 300 yards. This last year I took 2 'yotes at 300 yards (by laser rangefinder) holding dead on. You just need to remember to hold a tiny bit low for close-range shots. What fun!