I use a 22-250 for 90% of my predator calling. The best load I have found for minimal pelt damage is the following:
55 gr. #1365 Sierra SPBT, 39.0 grs. Big Game, Win Brass, BR-2 Primer
3650 fps.-.5" @ 100 yds.
The 50 gr. Nosler BT's come in second, but you can still get a blow-up on the shoulder if your shot is not perfect. The BT's are a bit stouter than the V-Max's and the other more frangible bullets.
The 53 gr. TSX's will work as well, but no better than the trusty ol' Sierra's though.
The bottom line is that it is still a 22-250...........not the most fur friendly round.