I've had a few 22-250s over the years. I've had alot of fun with them. I've never sold one because I didn't like it, just sold the one to a brother to get him in the yote hunting game.
My go to coyote/varmint rifle is a Tikka T3, 22-250. It's deadly accurate and I've put upwards of 1000 rounds through it. It still shoots very well, but not quite the 1/4 MOA it used to do. When the barrel finally goes on it, I'll get a new barrel put on in 22-250 again. Maybe 22-250 AI.
I've got a Shilen barrelled Stevens 200. 26" 1:7" varmint contour. I haven't had a chance to shoot it yet, but I plan on shooting the 75gr. Amax through it. Should be a deadly combo.
I shoot mostly the 52gr. Hornady Amax through my factory 1:14" barrel on my Tikka. 50gr. Hornady SP shoot very well also for me. And they work well for my brother in his Browning BLR I sold him.