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The 6BR is a great cartridge, but I don't think it will give you the performance you are wanting on yotes beginning @ 500 yards and further.
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.243 Win then? Geez, this sounds like it is starting to get into high levels of recoil.
And $1800+ might be a deal breaker on the HS. I think that is about the point at which I would go the custom route and not fight a right-handed action. I would think a left bolt, left port gun would be better for a right-handed shooter. Still $1000 less than a complete rifle though. . .