I haven't really made any long-range shots with a handgun, as compared to some on this site.
I mainly hunt with a handgun in my home state of MS, in heavily timbered terrain. I use a TC Contender with either a 309JDJ w/a red-dot scope or a 375JDJ w/a 2-7x Nikon.
I have taken two whitetail bucks with the 309. The first was a 120's 8pt @ 45yds, he was quartering towards my treestand at a good pace. I picked out an opening and brought him to a screeching halt.(Never would have hit him without the red-dot)
The second buck was a 137" 10pt @ 80yds. Once again I was in a treestand and he came crusing down a trail checking for a hot doe. I never tried to make him stop, I just put the dot behind the shoulder and dropped the hammer.
"GOD, GUTS, AND GUNS MADE AMERICA FREE" AND I'M KEEPING ALL THREE!