So far my 10mm is the only handgun other than my Contenders that I do not cast for.
That said, it isn't because I feel it would be problematic it's just due to the fact I have a huge supply of jacketed for it and haven't purchased a mold as of yet.
My standard load uses the 180gr Gold Dot and it is very accurate out as far as you feel up to holding the sights still. Usually 2" or so groups at 50yds are pretty easily accomplished.
I never ran many of the 200's through it as the GD mentioned above never gave me cause to. Out to 50yds they hit plenty hard drive at 1350fps from the muzzle of my IAI Javelina. They put he smack down on quite few feral hogs with one shot stops being pretty regular when I was toting it around.
Personally if I were looking into picking one up for hunting, I would look into the 1911 type frames and something with a 6-7" barrel on it. This way you will be able to get better velocity from the heavier bullets using the slower powders like AA-9 without building up the top end pressures.
I mentioned above I don't load cast YET, I will and will probably jump on one of the nicely made MP molds if he builds one in the right weight range I am looking for. He has or had one going for a light weight but I felt I would rather save for the heavy version instead. If your not familiar with the MP molds give a look over on Castboolits, and you will find plenty of them pictured with just a simple search. They usually come with at least one or more set of hollow point pins and a set of blank ones for solids. Then again I might simply contact NOE molds and have one built by them in a weight and design that mimics the GD, but will alloy a heavier weight bullet.
As to hunting with cast HP's or carrying them for woods type protection, their performance is all in the alloy. I have been tweaking mine with other calibers ranging from 357, 41, 44, and 45 Colt, and have what I feel is about right for each velocity for retained weight and penetration. The only drawback is you give up some penetration with the rapid expansion, but with that expansion you get some pretty heavy shock value as well. Control the alloy, and you also control the expansion. That is just the way with cast, it is a give and take game all the way around. But even without using a HP I can still get adequate expansion from my solids if I am wanting too.
Those are loaded for my Ruger Redhawk in 45 Colt over a health dose of HS-6 and are running just about 1200fps. I have only shot one big boar of around 250# with them, and to be honest the shots weren't really aimed. He came right up behind the grandson and I and was within 15ft when I drew and fired the first shot and less than 20 for the second. I hit him with both and spun him completely around with each before he got enough footing to get into the brush and away. He didn't go far, but fat plugged the exits and we lost him to the heat of the day.