Check out the following link:
22-250 Cartridge Guide within AccurateShooter.com
There is some excellent information contained in that article that should answer nearly any conceivable question about reloading for the 22-250.
As for accuracy expectation, that is highly dependent on what you intend to do with your rifle. If it is a lighter sporter intended for predator hunting, MOA or better with factory ammo is sufficient. However, if you intend to varmint hunt with it, you will want more in the neighborhood of 1/2 MOA with factory ammo (or at least a good handload).
FYI, I recently had my 22-250 re-barreled because it wouldn't shoot factory ammo under an inch @ 100 yards and my best handloads couldn't do better than .6" @ 100 yards. I wasn't happy with that. YMMV...