There is no "most accurate load" setting or result in QuickLoad, Sorry.
What it can do though is point you in the right direction when it comes to personal pereferences for % of case fill, pressure curves etc. etc. There are a lot of parameters that people look at when trying to get QL to lead them to a "magic" combination.
Just remember that it's a computer program and the results are based on what you put in, how precise your data and info is and what you do with it once it's in there.
It's a program that will take some time to get used to but once you get the hang of all of the ins and outs it will get you very close. As with all reloading however you're advised to "start low and work up" which is just standard practice. QL just helps you come up with some "educated guesses" as to what will be an efficient load. Whether or not it will be accurate in your gun and under your conditions can only be proven by putting some down range.