Originally Posted by Kevin Rohrer
The 22/250 really likes IMR4064 and H380 with either 50 or 55gr bullets. Everything else is secondary.
No doubt that H380 has a following for the 22-250, and much history as well. That being said, it is a powder that is highly temperature sensitive - if you are planning to shoot in both hot and cold seasons, it may not be a good choice.
On a personal note, I never found an H380 load for my 22-250 that allowed it to shoot to its full accuracy potential. My rifle certainly doesn't fit the "everything else is secondary" statement.